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General pharmacology mnemonics

GENERAL PHARMACOLOGY MNEMONICS

HMG-CoA reductase inhibitors (statins): side effects, contraindications, interactions
HMG-CoA:
*Side effects:
  • Hepatotoxicity
  • Myositis [aka rhabdomyolysis]
  *Contraindications:
  • Girl during pregnancy/ Growing children
  *Interactions:
  • Coumarin/ Cyclosporine
Lead poisoning: presentation
ABCDEFG:
  • Anemia
  • Basophilic stripping
  • Colicky pain
  • Diarrhea
  • Encephalopathy
  • Foot drop
  • Gum (lead line)
Lithium: side effects
LITHIUM:
  • Leukocytes Increased (leukocytosis)
  • Tremors
  • Hypothyroidism
  • Increased Urine
  • Moms beware (teratogenic)
Lupus: drugs inducing it
SHIPPP:
  • Sulfonamides
  • Hydralazine
  • INH
  • Procanimide
  • Penicillamine
  • Phenytoin
MAOIs: indications
MAOI'S:
  • Melancholic [classic name for atypical depression]
  • Anxiety
  • Obesity disorders [anorexia, bulemia]
  • Imagined illnesses [hypochondria]
  • Social phobias
  *Listed in decreasing order of importance.
  *Note MAOI is inside MelAnchOlIc.
Metabolism enzyme inducers
"Randy's Black Car Goes Putt Putt and Smokes":
  • Rifampin
  • Barbiturates
  • Carbamazepine
  • Grisoefulvin
  • Phenytoin
  • Phenobarb
  • Smoking cigarettes
Microtubules: drugs that act on microtubules.
"The MicroTubule Growth Voiding Chemicals":
  • Thiabendazole
  • Mebendazole
  • Taxol
  • Griseofulvin
  • Vincristine/ Vinblastine
  • Colchicine
Monoamine oxidase inhibitors: members
"PIT of despair":
  • Phenelzine
  • Isocarboxazid
  • Tranylcypromine
  *A pit of despair, since MAOs treat depression.
MPTP: mechanism, effect
MPTP:
  • Mitochondrial Parkinson's-Type Poison.
  *A mitochondrial poison that elicits a Parkinson's-type effect.
Routes of entry: most rapid ways meds/toxins enter body
"Stick it, Sniff it, Suck it, Soak it":
  • Stick = Injection
  • Sniff = inhalation
  • Suck = ingestion
  • Soak = absorption
Serotonin syndrome: components
Causes HARM:
  • Hyperthermia
  • Autonomic instability (delirium)
  • Rigidity
  • Myoclonus
Sodium valproate: side effects
VALPROATE:
  • Vomiting
  • Alopecia
  • Liver toxicity
  • Pancreatitis/ Pancytopenia
  • Retention of fats (weight gain)
  • Oedema (peripheral oedema)
  • Appetite increase
  • Tremor
  • Enzyme inducer (liver)
SSRIs: side effects
SSRI:
  • Serotonin syndrome
  • Stimulate CNS
  • Reproductive disfunctions in male
  • Insomnia
Succinylcholine: action, use
  • Succinylcholine gets Stuck to Ach receptor, then Sucks ions in through open pore.
  • You Suck stuff in through a mouth-tube, and drug is used for intubation.
Therapeutic dosage: toxicity values for most commonly monitored medications
"The magic 2s":
  • Digitalis (.5-1.5) Toxicity = 2.
  • Lithium (.6-1.2) Toxicity = 2.
  • Theophylline (10-20) Toxicity = 20.
  • Dilantin (10-20) Toxicity = 20.
  • APAP (1-30) Toxicity = 200.
Therapeutic index: formula
TILE:
  • TI = LD50 / ED50
Zero order kinetics drugs (most common ones)
"PEAZ (sounds like pees) out a constant amount":
  • Phenytoin
  • Ethanol
  • Aspirin
  • Zero order
  *Someone that pees out a constant amount describes zero order kinetics (always the same amount out)

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