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GENERAL PHARMACOLOGY MNEMONICS
HMG-CoA reductase inhibitors (statins): side effects, contraindications, interactions
HMG-CoA:
*Side effects:
- Hepatotoxicity
- Myositis [aka rhabdomyolysis]
*Contraindications:
- Girl during pregnancy/ Growing children
*Interactions:
- Coumarin/ Cyclosporine
Lead poisoning: presentation
ABCDEFG:
- Anemia
- Basophilic stripping
- Colicky pain
- Diarrhea
- Encephalopathy
- Foot drop
- Gum (lead line)
Lithium: side effects
LITHIUM:
- Leukocytes Increased (leukocytosis)
- Tremors
- Hypothyroidism
- Increased Urine
- Moms beware (teratogenic)
Lupus: drugs inducing it
SHIPPP:
- Sulfonamides
- Hydralazine
- INH
- Procanimide
- Penicillamine
- Phenytoin
MAOIs: indications
MAOI'S:
- Melancholic [classic name for atypical depression]
- Anxiety
- Obesity disorders [anorexia, bulemia]
- Imagined illnesses [hypochondria]
- Social phobias
*Listed in decreasing order of importance.
*Note MAOI is inside MelAnchOlIc.
Metabolism enzyme inducers
"Randy's Black Car Goes Putt Putt and Smokes":
- Rifampin
- Barbiturates
- Carbamazepine
- Grisoefulvin
- Phenytoin
- Phenobarb
- Smoking cigarettes
Microtubules: drugs that act on microtubules.
"The MicroTubule Growth Voiding Chemicals":
- Thiabendazole
- Mebendazole
- Taxol
- Griseofulvin
- Vincristine/ Vinblastine
- Colchicine
Monoamine oxidase inhibitors: members
"PIT of despair":
- Phenelzine
- Isocarboxazid
- Tranylcypromine
*A pit of despair, since MAOs treat depression.
MPTP: mechanism, effect
MPTP:
- Mitochondrial Parkinson's-Type Poison.
*A mitochondrial poison that elicits a Parkinson's-type effect.
Routes of entry: most rapid ways meds/toxins enter body
"Stick it, Sniff it, Suck it, Soak it":
- Stick = Injection
- Sniff = inhalation
- Suck = ingestion
- Soak = absorption
Serotonin syndrome: components
Causes HARM:
- Hyperthermia
- Autonomic instability (delirium)
- Rigidity
- Myoclonus
Sodium valproate: side effects
VALPROATE:
- Vomiting
- Alopecia
- Liver toxicity
- Pancreatitis/ Pancytopenia
- Retention of fats (weight gain)
- Oedema (peripheral oedema)
- Appetite increase
- Tremor
- Enzyme inducer (liver)
SSRIs: side effects
SSRI:
- Serotonin syndrome
- Stimulate CNS
- Reproductive disfunctions in male
- Insomnia
Succinylcholine: action, use
- Succinylcholine gets Stuck to Ach receptor, then Sucks ions in through open pore.
- You Suck stuff in through a mouth-tube, and drug is used for intubation.
Therapeutic dosage: toxicity values for most commonly monitored medications
"The magic 2s":
- Digitalis (.5-1.5) Toxicity = 2.
- Lithium (.6-1.2) Toxicity = 2.
- Theophylline (10-20) Toxicity = 20.
- Dilantin (10-20) Toxicity = 20.
- APAP (1-30) Toxicity = 200.
Therapeutic index: formula
TILE:
- TI = LD50 / ED50
Zero order kinetics drugs (most common ones)
"PEAZ (sounds like pees) out a constant amount":
- Phenytoin
- Ethanol
- Aspirin
- Zero order
*Someone that pees out a constant amount describes zero order kinetics (always the same amount out)
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