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Sickle cell crisis or Sickle cell anemia :- 1- hand foot syndrome 2-hemolytic crisis 3- vaso- oclusive or pain crisis 4- aplastic crisis  or parvovirus   5- acute abdomen 6- sequestration crisis Complication of sickle cell anemia 1- stroke 2- heart failure 3- "crew cut" 4-acute chest syndrome 5- auto splenoctomy 6-renal failure 7- parpism 8- leg ulcer 9- extra medullary hematopoiesis 10-hemosidrosis and pigmented gall stone Investigation  1- blood smear. 2- electrophoresis Treatment  Bone marrow transplantation